The sculpture collection contains works from the 18th century through to the present day. The highlight is the collection of neoclassical sculpture by Joseph Nollekens, John Gibson and John Bacon, presented to the Usher Gallery in 1930 by the Earl of Yarborough. These marble sculptures are very fine examples of neoclassical art, inspired by Roman and Greek antique sculpture.

Sculptures from artists working at the turn of the 20th century are represented in works by Jacob Epstein and Lincolnshire sculptor Ella Curtois. Contemporary sculptures include a large bronze, A Mighty Blow for Freedom, by Michael Sandle, works in stone by Richard Devereux, Keir Smith and Peter Randall-Page, and pieces by Maggi Hambling and Edward Allington. A sculptural chandelier made from plastic debris washed up by the sea by Stuart Haygarth, hangs in the Usher Gallery entrance hall.

A small collection of busts features likenesses of poets, musicians, scientists, political and military leaders and distinguished personalities. The collection also contains examples of bronze and plaster medals by the notable sculptor Artur Loewental.